Lumbar disc herniation (LDH) can be spontaneously absorbed without surgical treatment. However, the pathogenesis and physiological indications for predicting protrusion reabsorption are still unclear, which prevents clinicians from preferentially choosing conservative treatment options for LDH patients with reabsorption effects. The purpose of this review was to summarize previous reports on LDH reabsorption and to discuss the clinical and imaging features that favor natural absorption. We highlighted the biological mechanisms involved in the phenomenon of LDH reabsorption, including macrophage infiltration, inflammatory responses, matrix remodeling, and neovascularization. In addition, we summarized and discussed potential clinical treatments for promoting reabsorption. Current evidence suggests that macrophage regulation of inflammatory mediators, matrix metalloproteinases, and specific cytokines in intervertebral disc is essential for the spontaneous reabsorption of LDH.
Lumbar Discogenic Pain - Physiopedia
About resorption Innovating approaches based on science
A stratified comparison (based on lumbar spine location) of disc
Schematic model demonstrating the mechanism of herniated disc
Neurospine
The main mechanism of reabsorption of herniated disc. A herniated
PDF) Characteristics and mechanisms of resorption in lumbar disc
Can Herniated Discs Heal on Their Own?
PDF] The predictive factors for the resorption of a lumbar disc herniation on plain MRI.
