Author Summary MicroRNAs play pervasive roles in controlling gene expression throughout animal development. Given that individual microRNAs are predicted to regulate hundreds of mRNAs and that most mRNA transcripts are microRNA targets, it is essential that the expression levels of microRNAs be tightly regulated. With the goal of unveiling factors that regulate the expression of microRNAs that control developmental timing, we identified lin-42, the C. elegans homolog of the human and Drosophila period gene implicated in circadian gene regulation, as a negative regulator of microRNA expression. By analyzing the transcriptional expression patterns of representative microRNAs, we found that the transcription of many microRNAs is normally highly dynamic and coupled aspects of post-embryonic growth and behavior. We suggest that lin-42 functions to modulate the transcriptional output of temporally-regulated microRNAs and mRNAs in order to maintain optimal expression of these genes throughout development.
PDF) Tumour-related microRNAs functions in Caenorhabditis elegans
LIN-42, the Caenorhabditis elegans PERIOD homolog, Negatively Regulates MicroRNA Transcription
Period homolog LIN-42 regulates miRNA transcription to impact developmental timing. - Abstract - Europe PMC
General Principals of miRNA Biogenesis and Regulation in the Brain
Figure 6 from Conservation of mRNA and protein expression during development of C. elegans.
IJMS, Free Full-Text
The Period protein homolog LIN-42 regulates germline development in C. elegans - ScienceDirect
Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans
LIN-42, the Caenorhabditis elegans PERIOD homolog, Negatively Regulates MicroRNA Transcription
lin-42 mutations lead to the overexpression of several miRNAs. (A)
The Period protein homolog LIN-42 regulates germline development in C. elegans - ScienceDirect
PDF) The Doubletime Homolog KIN-20 Mainly Regulates let-7 Independently of Its Effects on the Period Homolog LIN-42 in Caenorhabditis elegans
Roberto PERALES, Postdoctoral Fellow, PhD, Harvard Medical School, MA, HMS, Department of Genetics
